Compounds > 1-phenyl-2-[[4-(trifluoromethyl)phenyl]methylthio]imidazole
Page last updated: 2024-08-01 02:12:16

1-phenyl-2-[[4-(trifluoromethyl)phenyl]methylthio]imidazole

Description

1-phenyl-2-[[4-(trifluoromethyl)phenyl]methylthio]imidazole : no description available [CHeBI]

Cross-References

ID SourceID
PubMed CID3696046
CHEMBL ID1390514
CHEBI ID114906

Synonyms (19)

Synonym
smr000179722
MLS000327069 ,
1-phenyl-2-{[4-(trifluoromethyl)benzyl]sulfanyl}-1h-imidazole
CHEBI:114906
AKOS005089192
1-phenyl-2-[[4-(trifluoromethyl)phenyl]methylsulfanyl]imidazole
HMS2273D05
3R-0242
478040-08-3
1-phenyl-2-({[4-(trifluoromethyl)phenyl]methyl}sulfanyl)-1h-imidazole
cid_3696046
1-phenyl-2-[[4-(trifluoromethyl)phenyl]methylthio]imidazole
1-phenyl-2-[[4-(trifluoromethyl)benzyl]thio]imidazole
bdbm68853
CHEMBL1390514
Q27196749
HY-153930
CS-0867134
h15-lox-2 inhibitor 1

Drug Classes (1)

ClassDescription
imidazolesA five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton.

Protein Targets (21)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency0.2818AID2517
glp-1 receptor, partialHomo sapiens (human)Potency7.0795AID624417
TDP1 proteinHomo sapiens (human)Potency23.1093AID686978; AID686979
Smad3Homo sapiens (human)Potency6.3096AID588855
apical membrane antigen 1, AMA1Plasmodium falciparum 3D7Potency25.1189AID720542
bromodomain adjacent to zinc finger domain 2BHomo sapiens (human)Potency39.8107AID504333
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency44.6684AID504332
chromobox protein homolog 1Homo sapiens (human)Potency56.2341AID540317
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency14.1254AID2551
lethal(3)malignant brain tumor-like protein 1 isoform IHomo sapiens (human)Potency15.8489AID485360
Polyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)Potency15.8489AID881
Histamine H2 receptorCavia porcellus (domestic guinea pig)Potency15.8489AID881
Inositol monophosphatase 1Rattus norvegicus (Norway rat)Potency28.1838AID1457
Rap guanine nucleotide exchange factor 4Homo sapiens (human)Potency79.4328AID720708

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)
Polyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)IC500.3400AID1766300
Polyunsaturated fatty acid lipoxygenase ALOX8Mus musculus (house mouse)IC5050.0000AID1766306
Polyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)IC50100.0000AID1766305
Polyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)IC5050.0000AID1766303
Polyunsaturated fatty acid lipoxygenase ALOX12Homo sapiens (human)IC50100.0000AID1766304
Prostaglandin G/H synthase 1Homo sapiens (human)IC50100.0000AID1766307
Prostaglandin G/H synthase 2Homo sapiens (human)IC50100.0000AID1766308

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)
glycogen synthase kinase-3 beta isoform 1Homo sapiens (human)EC50300.0000AID434954
Polyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)EC500.7500AID1766313

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)
Polyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)Kic0.7000AID1766301
Polyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)Kiuc1.2000AID1766302

Bioassays (25)

Assay IDTitleYearJournalArticle
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
ISSN: 1945-7170		A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression2022The Journal of biological chemistry, 08, Volume: 298, Issue:8
ISSN: 1083-351X
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13ISSN: 1934-9300Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
ISSN: 1552-4922		Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
ISSN: 1557-8127		High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1745845Primary qHTS for Inhibitors of ATXN expression2022The Journal of biological chemistry, 08, Volume: 298, Issue:8
ISSN: 1083-351X
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13ISSN: 1934-9300Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
ISSN: 1552-4922		Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
ISSN: 1557-8127		High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
ISSN: 1945-7170		A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13ISSN: 1934-9300Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
ISSN: 1552-4922		Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
ISSN: 1557-8127		High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1766316Selectivity ratio of IC50 for inhibition of human COX1 to IC50 for inhibition of human 15-LOX-22021Bioorganic & medicinal chemistry, 09-15, Volume: 46ISSN: 1464-3391Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2.
AID1766300Inhibition of human 15-LOX-2 assessed as enzymatic rate using arachidonic acid as substrate by UV/Vis spectrophotometric analysis2021Bioorganic & medicinal chemistry, 09-15, Volume: 46ISSN: 1464-3391Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2.
AID1766311Pseudo-peroxidase activity in human 15-LOX-2 assessed as redox activity of the compound by measuring degradation of 13-HpODE at 20 uM by UV/Vis pseudo-peroxidase assay2021Bioorganic & medicinal chemistry, 09-15, Volume: 46ISSN: 1464-3391Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2.
AID1766310Selectivity ratio of IC50 for inhibition of human 12-LOX to IC50 for inhibition of human 15-LOX-22021Bioorganic & medicinal chemistry, 09-15, Volume: 46ISSN: 1464-3391Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2.
AID1766302Uncompetitive inhibition of human 15-LOX-2 assessed as equilibrium dissociation constant from secondary site by measuring 15-HpETE by Dixon plots and Dixon replots analysis2021Bioorganic & medicinal chemistry, 09-15, Volume: 46ISSN: 1464-3391Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2.
AID1766305Inhibition of human 5-LOX assessed as enzymatic rate using arachidonic acid as substrate by UV/Vis spectrophotometric analysis2021Bioorganic & medicinal chemistry, 09-15, Volume: 46ISSN: 1464-3391Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2.
AID1766301Competitive inhibition of human 15-LOX-2 assessed as equilibrium dissociation constant from catalytic site by measuring 15-HpETE by Dixon plots and Dixon replots analysis2021Bioorganic & medicinal chemistry, 09-15, Volume: 46ISSN: 1464-3391Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2.
AID1766315Selectivity ratio of IC50 for inhibition of human 5-LOX to IC50 for inhibition of human 15-LOX-22021Bioorganic & medicinal chemistry, 09-15, Volume: 46ISSN: 1464-3391Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2.
AID1766308Inhibition of human recombinant COX-2 assessed as enzymatic rate using arachidonic acid as substrate by UV/Vis spectrophotometric analysis2021Bioorganic & medicinal chemistry, 09-15, Volume: 46ISSN: 1464-3391Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2.
AID1766317Selectivity ratio of IC50 for inhibition of human COX2 to IC50 for inhibition of human 15-LOX-22021Bioorganic & medicinal chemistry, 09-15, Volume: 46ISSN: 1464-3391Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2.
AID1766313Inhibition of human 15-LOX-2 expressed in HEK293T cells assessed as a reduction in 15-HETE production using arachidonic acid as substrate incubated for 20 mins2021Bioorganic & medicinal chemistry, 09-15, Volume: 46ISSN: 1464-3391Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2.
AID1766307Inhibition of human recombinant COX-1 assessed as enzymatic rate using arachidonic acid as substrate by UV/Vis spectrophotometric analysis2021Bioorganic & medicinal chemistry, 09-15, Volume: 46ISSN: 1464-3391Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2.
AID1766306Inhibition of mouse 15-LOX2 assessed as enzymatic rate using arachidonic acid as substrate by UV/Vis spectrophotometric analysis2021Bioorganic & medicinal chemistry, 09-15, Volume: 46ISSN: 1464-3391Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2.
AID1766309Selectivity ratio of IC50 for inhibition of human 15-LOX-1 to IC50 for inhibition of human 15-LOX-22021Bioorganic & medicinal chemistry, 09-15, Volume: 46ISSN: 1464-3391Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2.
AID1766312Substrate activity at human 15-LOX-2 assessed as chemical reaction by RP-HPLC analysis2021Bioorganic & medicinal chemistry, 09-15, Volume: 46ISSN: 1464-3391Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2.
AID1766314Cytotoxicity against human HEK293T cells expressing human 15-LOX-2 at 10 uM measured after 1 hr by cell survival assay2021Bioorganic & medicinal chemistry, 09-15, Volume: 46ISSN: 1464-3391Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2.
AID1766304Inhibition of human 12-LOX assessed as enzymatic rate using arachidonic acid as substrate by UV/Vis spectrophotometric analysis2021Bioorganic & medicinal chemistry, 09-15, Volume: 46ISSN: 1464-3391Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2.
AID1766303Inhibition of human 15-LOX-1 assessed as enzymatic rate using arachidonic acid as substrate by UV/Vis spectrophotometric analysis2021Bioorganic & medicinal chemistry, 09-15, Volume: 46ISSN: 1464-3391Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2.

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's3 (50.00)24.3611
2020's2 (33.33)2.80

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
histamine
0
aralkylamino compound;
imidazoles		human metabolite;
mouse metabolite;
neurotransmitter		00low000000
1-(2-trifluoromethylphenyl)imidazole
0
imidazoles00low000000
1-methylimidazole
0
imidazoles00low000000
4-imidazolemethanol
0
imidazoles;
primary alcohol		00low000000
alosetron
0
imidazoles;
pyridoindole		antiemetic;
gastrointestinal drug;
serotonergic antagonist		00low000000
azathioprine
0
aryl sulfide;
C-nitro compound;
imidazoles;
thiopurine		antimetabolite;
antineoplastic agent;
carcinogenic agent;
DNA synthesis inhibitor;
hepatotoxic agent;
immunosuppressive agent;
prodrug		00low000000
bay h 4502
0
biphenyls;
imidazoles		00low000000
brimonidine
0
imidazoles;
quinoxaline derivative;
secondary amine		adrenergic agonist;
alpha-adrenergic agonist;
antihypertensive agent		00low000000
carcinine
0
beta-alanine derivative;
imidazoles;
monocarboxylic acid amide;
organonitrogen compound;
organooxygen compound		antioxidant;
crustacean metabolite		00low000000
cgp 20712a
0
imidazoles00low000000
cimetidine
0
aliphatic sulfide;
guanidines;
imidazoles;
nitrile		adjuvant;
analgesic;
anti-ulcer drug;
H2-receptor antagonist;
P450 inhibitor		00low000000
clobenpropit
0
imidazoles;
imidothiocarbamic ester;
organochlorine compound		H3-receptor antagonist;
H4-receptor agonist		00low000000
clotrimazole
0
conazole antifungal drug;
imidazole antifungal drug;
imidazoles;
monochlorobenzenes		antiinfective agent;
environmental contaminant;
xenobiotic		00low000000
dacarbazine
0
imidazoles;
monocarboxylic acid amide;
triazene derivative		alkylating agent;
antineoplastic agent;
carcinogenic agent;
prodrug		00low000000
dimetridazole
0
C-nitro compound;
imidazoles		antiparasitic agent;
antiprotozoal drug		00low000000
econazole
0
dichlorobenzene;
ether;
imidazoles;
monochlorobenzenes		00low000000
etanidazole
0
C-nitro compound;
imidazoles;
monocarboxylic acid amide		alkylating agent;
antineoplastic agent;
prodrug;
radiosensitizing agent		00low000000
flutrimazole
0
imidazole antifungal drug;
imidazoles;
monofluorobenzenes		EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor00low000000
tele-methylhistamine
0
imidazoles;
primary amino compound		human metabolite;
mouse metabolite		00low000000
alpha-methylhistamine
0
aralkylamino compound;
imidazoles		animal metabolite;
H3-receptor agonist		00low000000
imetit
0
imidazoles;
imidothiocarbamic ester		H3-receptor agonist;
H4-receptor agonist		00low000000
isoconazole
0
dichlorobenzene;
ether;
imidazoles		00low000000
ketoconazole
0
dichlorobenzene;
dioxolane;
ether;
imidazoles;
N-acylpiperazine;
N-arylpiperazine		00low000000
losartan
0
biphenylyltetrazole;
imidazoles		angiotensin receptor antagonist;
anti-arrhythmia drug;
antihypertensive agent;
endothelin receptor antagonist		00low000000
metronidazole
0
C-nitro compound;
imidazoles;
primary alcohol		antiamoebic agent;
antibacterial drug;
antimicrobial agent;
antiparasitic agent;
antitrichomonal drug;
environmental contaminant;
prodrug;
radiosensitizing agent;
xenobiotic		00low000000
miconazole
0
dichlorobenzene;
ether;
imidazoles		00low000000
pd 169316
0
imidazoles00low000000
ronidazole
0
C-nitro compound;
carbamate ester;
imidazoles		antiparasitic agent;
antiprotozoal drug		00low000000
sb 220025
0
aminopyrimidine;
imidazoles;
organofluorine compound;
piperidines		angiogenesis inhibitor;
anti-inflammatory agent;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor		00low000000
sb 239063
0
imidazoles00low000000
sb 202190
0
imidazoles;
organofluorine compound;
phenols;
pyridines		apoptosis inducer;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor		00low000000
sk&f 86002
0
imidazoles00low000000
sulconazole
0
dichlorobenzene;
imidazoles;
monochlorobenzenes;
organic sulfide		00low000000
tinidazole
0
imidazolesantiamoebic agent;
antibacterial drug;
antiparasitic agent;
antiprotozoal drug		00low000000
tioconazole
0
dichlorobenzene;
ether;
imidazoles;
thiophenes		00low000000
tizanidine
0
benzothiadiazole;
imidazoles		alpha-adrenergic agonist;
muscle relaxant		00low000000
tolazoline
0
imidazolesalpha-adrenergic antagonist;
antihypertensive agent;
vasodilator agent		00low000000
phentolamine
0
imidazoles;
phenols;
substituted aniline;
tertiary amino compound		alpha-adrenergic antagonist;
vasodilator agent		00low000000
azomycin
0
C-nitro compound;
imidazoles		antitubercular agent00low000000
5-methylbenzimidazole
0
imidazoles00low000000
2-methyl-5-nitroimidazole
0
C-nitro compound;
imidazoles		00low000000
4-methylimidazole
0
imidazolescarcinogenic agent;
reaction intermediate		00low000000
zolimidine
0
imidazoles00low000000
1,2-dimethylimidazole
0
imidazoles00low000000
4-nitroimidazole
0
C-nitro compound;
imidazoles		00low000000
metomidate
0
imidazoles00low000000
nimorazole
0
C-nitro compound;
imidazoles		00low000000
ipronidazole
0
C-nitro compound;
imidazoles		00low000000
ornidazole
0
C-nitro compound;
imidazoles;
organochlorine compound;
secondary alcohol		antiamoebic agent;
antibacterial drug;
antiinfective agent;
antiprotozoal drug;
antitrichomonal drug;
epitope		00low000000
1-(trimethylsilyl)-1h-imidazole
0
imidazoles;
N-silyl compound		chromatographic reagent00low000000
lofexidine
0
aromatic ether;
carboxamidine;
dichlorobenzene;
imidazoles		alpha-adrenergic agonist;
antihypertensive agent		00low000000
benzonidazole
0
C-nitro compound;
imidazoles;
monocarboxylic acid amide		antiprotozoal drug00low000000
etomidate
0
imidazoles00low000000
enilconazole
0
dichlorobenzene;
ether;
imidazoles		00low000000
4-methylhistamine
0
aralkylamino compound;
imidazoles		histamine agonist;
metabolite		00low000000
climbazole
0
aromatic ether;
hemiaminal ether;
imidazoles;
ketone;
monochlorobenzenes		00low000000
butoconazole nitrate
0
aryl sulfide;
conazole antifungal drug;
imidazole antifungal drug;
imidazoles;
organic nitrate salt		00low000000
butoconazole
0
aryl sulfide;
conazole antifungal drug;
dichlorobenzene;
imidazole antifungal drug;
imidazoles;
monochlorobenzenes		00low000000
oxmetidine
0
benzodioxoles;
imidazoles;
pyrimidone		anti-ulcer drug;
H2-receptor antagonist		00low000000
fenticonazole
0
aryl sulfide;
dichlorobenzene;
ether;
imidazoles		00low000000
alpidem
0
imidazoles00low000000
2-(2-methoxy-4-(methylsulfinyl)phenyl)-1h-imidazo(4,5-c)pyridine
0
imidazoles00low000000
sertaconazole
0
1-benzothiophenes;
dichlorobenzene;
ether;
imidazoles		00low000000
medetomidine
0
imidazoles00low000000
zoledronic acid
0
1,1-bis(phosphonic acid);
imidazoles		bone density conservation agent00low000000
n-acetylhistamine
0
acetamides;
imidazoles		human metabolite00low000000
5-imidazolepropionic acid
0
imidazoles;
monocarboxylic acid		00low000000
secnidazole
0
C-nitro compound;
imidazoles;
secondary alcohol		epitope00low000000
nitrefazole
0
imidazoles00low000000
eberconazole
0
dibenzannulene;
imidazoles;
organochlorine compound		00low000000
prochloraz
0
amide fungicide;
aromatic ether;
conazole fungicide;
imidazole fungicide;
imidazoles;
trichlorobenzene;
ureas		antifungal agrochemical;
EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor;
environmental contaminant;
xenobiotic		00low000000
methylimidazoleacetic acid
0
imidazoles;
monocarboxylic acid		GABA agonist;
metabolite		00low000000
5-(3-methyl-1-triazeno)imidazole-4-carboxamide
0
imidazoles;
monocarboxylic acid amide;
triazene derivative		alkylating agent;
antineoplastic agent		00low000000
1-(3-aminopropyl)imidazole
0
imidazoles00low000000
1-ethyl-2-benzimidazolinone
0
imidazoles00low000000
2-methylhistamine
0
aralkylamino compound;
imidazoles		histamine agonist;
metabolite		00low000000
imidazoleacetic acid
0
imidazoles;
monocarboxylic acid		metabolite;
mouse metabolite		00low000000
mizoribine
0
imidazolesanticoronaviral agent00low000000
1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1h-imidazole
0
ether;
imidazoles;
monomethoxybenzene		TRP channel blocker00low000000
exp3174
0
biphenylyltetrazole;
imidazoles;
organochlorine compound		metabolite00low000000
1-(2-hydroxyethyl)-2-hydroxymethyl-5-nitroimidazole
0
C-nitro compound;
imidazoles		00low000000
histidinal
0
amino aldehyde;
imidazoles		00low000000
alpha-methylhistamine
0
aralkylamino compound;
imidazoles		H3-receptor agonist00low000000
tipifarnib
0
imidazoles;
monochlorobenzenes;
primary amino compound;
quinolone		antineoplastic agent;
apoptosis inducer;
EC 2.5.1.58 (protein farnesyltransferase) inhibitor		00low000000
histidinol
0
amino alcohol;
imidazoles		EC 2.3.1.97 (glycylpeptide N-tetradecanoyltransferase) inhibitor;
Escherichia coli metabolite;
human metabolite;
Saccharomyces cerevisiae metabolite		00low000000
sb 203580
0
imidazoles;
monofluorobenzenes;
pyridines;
sulfoxide		EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor;
geroprotector;
Hsp90 inhibitor;
neuroprotective agent		00low000000
fk 1052
0
imidazoles;
organic heterotricyclic compound		antiemetic;
serotonergic antagonist		00low000000
cimicoxib
0
aromatic ether;
imidazoles;
organochlorine compound;
organofluorine compound;
sulfonamide		cyclooxygenase 2 inhibitor;
non-steroidal anti-inflammatory drug		00low000000
dabuzalgron
0
aromatic ether;
imidazoles;
monochlorobenzenes;
sulfonamide		alpha-adrenergic agonist00low000000
l 778,123
0
imidazoles;
monochlorobenzenes;
nitrile;
piperazinone;
tertiary amino compound		antineoplastic agent;
EC 2.5.1.58 (protein farnesyltransferase) inhibitor;
EC 2.5.1.59 (protein geranylgeranyltransferase type I) inhibitor		00low000000
1-methylpropyl-2-imidazolyl disulfide
0
imidazoles00low000000
2-pentan-3-yl-1H-imidazole
0
imidazoles00low000000
2-(1-adamantyl)imidazole
0
imidazoles00low000000
6-(4-chlorophenyl)-2,3-dihydroimidazo[2,1-b]thiazole
0
imidazoles00low000000
bromodeoxytopsentin
0
aromatic ketone;
bromoindole;
imidazoles;
indole alkaloid		antibacterial agent;
EC 2.7.1.40 (pyruvate kinase) inhibitor;
marine metabolite		00low000000
pifithrin-beta
0
imidazoles00low000000
bms 214662
0
benzenes;
benzodiazepine;
imidazoles;
nitrile;
sulfonamide;
thiophenes		antineoplastic agent;
apoptosis inducer;
EC 2.5.1.58 (protein farnesyltransferase) inhibitor		00low000000
histidyl-proline diketopiperazine
0
dipeptide;
homodetic cyclic peptide;
imidazoles;
pyrrolopyrazine		anti-inflammatory agent;
dopamine uptake inhibitor;
human blood serum metabolite		00low000000
s 1033
0
(trifluoromethyl)benzenes;
imidazoles;
pyridines;
pyrimidines;
secondary amino compound;
secondary carboxamide		anticoronaviral agent;
antineoplastic agent;
tyrosine kinase inhibitor		00low000000
N-[1-methyl-5-(4-methylphenyl)-2-imidazolyl]-4-oxo-4-(1-piperidinyl)butanamide
0
imidazoles00low000000
2-[[5-(4-fluorophenyl)-1-methyl-2-imidazolyl]thio]-1-(1-piperidinyl)ethanone
0
imidazoles00low000000
2-[[5-(4-chlorophenyl)-1-(2-methoxyethyl)-2-imidazolyl]thio]-N-(thiophen-2-ylmethyl)acetamide
0
imidazoles00low000000
2-(4-chlorophenyl)-3-(2-furanylmethyl)imidazo[4,5-b]quinoxaline
0
imidazoles00low000000
2-(4-methoxyphenyl)-3-propylimidazo[4,5-b]quinoxaline
0
imidazoles00low000000
etomidate
0
ethyl ester;
imidazoles		intravenous anaesthetic;
sedative		00low000000
4-(3-amino-2-imidazo[1,2-a]pyridinyl)-2-methoxyphenol
0
imidazoles00low000000
aeg 3482
0
imidazoles00low000000
2-(3,4-dichlorophenyl)imidazo[1,2-a]pyrimidine
0
imidazoles00low000000
1-hydroxy-2-phenyl-1,5,6,7-tetrahydro-4H-benzimidazol-4-one
0
imidazoles00low000000
3-(4-methoxyphenyl)imidazo[1,5-a]pyridine
0
imidazoles00low000000
N-(2-phenyl-3-imidazo[1,2-a]pyridinyl)carbamic acid methyl ester
0
imidazoles00low000000
N-[3-(6-imidazo[2,1-b]thiazolyl)phenyl]butanamide
0
imidazoles00low000000
N-(6-phenyl-5-imidazo[2,1-b]thiazolyl)benzamide
0
imidazoles00low000000
2-phenyl-3-imidazo[1,2-a]pyridinecarboxaldehyde
0
imidazoles00low000000
N-(2-phenyl-6-imidazo[1,2-a]pyridinyl)acetamide
0
imidazoles00low000000
N,N-dimethylcarbamic acid [4-[6-(trifluoromethyl)-2-imidazo[1,2-a]pyridinyl]phenyl] ester
0
imidazoles00low000000
2-(2-furanyl)-3-(4-methylphenyl)imidazo[4,5-b]quinoxaline
0
imidazoles00low000000
2-[(1,5-diphenyl-2-imidazolyl)thio]-N-(2-furanylmethyl)acetamide
0
imidazoles00low000000
4-chloro-2-[[(1-methyl-5-phenyl-2-imidazolyl)amino]methyl]phenol
0
imidazoles00low000000
5-(4-bromophenyl)-1-methyl-N-(3-pyridinylmethyl)-2-imidazolamine
0
imidazoles00low000000
N'-methyl-N-[1-methyl-5-(4-methylphenyl)-2-imidazolyl]-N'-(phenylmethyl)butanediamide
0
imidazoles00low000000
5-(4-fluorophenyl)sulfonyl-1-(2-methylpropyl)-4-nitro-2-propan-2-ylimidazole
0
imidazoles00low000000
2-(3,5-dinitrophenyl)-3-(2-phenylethyl)imidazo[4,5-b]quinoxaline
0
imidazoles00low000000
2-(4-methylsulfonylphenyl)-6-imidazo[1,2-a]pyridinecarboxylic acid methyl ester
0
imidazoles00low000000
1-[[[1-(6-methyl-2-pyridinyl)-4-imidazolyl]-oxomethyl]amino]-3-phenylthiourea
0
imidazoles00low000000
metiamide
0
imidazoles00low000000
4,5-dichloro-2-methyl-1-(2-phenoxyethyl)imidazole
0
imidazoles00low000000
2-Chloro-6-(1H-imidazol-1-yl)benzonitrile
0
imidazoles00low000000
[1-Benzyl-2-(methylsulfanyl)-1H-imidazol-5-yl]methanol
0
imidazoles00low000000
2-(1-benzyl-1H-imidazol-5-yl)phenol
0
imidazoles00low000000
1-[2-(2,5-dimethyl-1H-pyrrol-1-yl)-4-nitrophenyl]-1H-imidazole
0
imidazoles00low000000
2-[4-(trifluoromethoxy)phenyl]imidazo[1,2-a]pyrimidine
0
imidazoles00low000000
6-methyl-2-[4-(1-piperidinylsulfonyl)phenyl]imidazo[1,2-a]pyridine
0
imidazoles00low000000
1-[(4-tert-butylphenyl)methyl]-4-(4-nitrophenyl)imidazole
0
imidazoles00low000000
burimamide
0
imidazoles00low000000
carnidazole
0
C-nitro compound;
imidazoles		00low000000
2-methoxy-4-[5-methyl-3-(2-oxolanylmethylamino)-2-imidazo[1,2-a]pyridinyl]phenol
0
imidazoles00low000000
4-[3-(1,3-benzodioxol-5-ylmethylamino)-7-methyl-2-imidazo[1,2-a]pyridinyl]phenol
0
imidazoles00low000000
2-[[5-(4-fluorophenyl)-1-methyl-2-imidazolyl]thio]-1-(2-methyl-2,3-dihydroindol-1-yl)ethanone
0
imidazoles00low000000
N-[3-(diethylamino)propyl]-6-(4-fluorophenyl)-3-methyl-2-imidazo[2,1-b]thiazolecarboxamide
0
imidazoles00low000000
N-(1,3-benzodioxol-5-yl)-3-methyl-6-phenyl-2-imidazo[2,1-b]thiazolecarboxamide
0
imidazoles00low000000
N-[5-(ethylthio)-1,3,4-thiadiazol-2-yl]-2-[[1-(3-methylphenyl)-2-imidazolyl]thio]acetamide
0
imidazoles00low000000
4-[[2-(4-methoxyphenyl)-6-imidazo[2,1-b][1,3]benzothiazolyl]-oxomethyl]-1-piperazinecarboxylic acid ethyl ester
0
imidazoles00low000000
4-[3-(2,3-dihydro-1,4-benzodioxin-6-ylamino)-2-imidazo[1,2-a]pyrimidinyl]phenol
0
imidazoles00low000000
5-(1,3-benzodioxol-5-yl)-3-[3-(methylthio)phenyl]-1H-imidazol-2-one
0
imidazoles00low000000
2-(2-ethoxyphenyl)-8-oxo-9-phenyl-7H-purine-6-carboxamide
0
imidazoles00low000000
1-[6-(4-chlorophenyl)-5-imidazo[2,1-b]thiazolyl]-N-[(3,4-dichlorophenyl)methoxy]methanimine
0
imidazoles00low000000
1-[4-(2-chlorophenoxy)butyl]imidazole
0
aromatic ether;
imidazoles;
monochlorobenzenes		00low000000
4-[(3-methyl-5-nitro-4-imidazolyl)amino]phenol
0
C-nitro compound;
imidazoles		00low000000
4-(4-ethoxyphenyl)-1-(4-methoxyphenyl)-2-(methylthio)imidazole
0
imidazoles00low000000
4-[(7-methyl-2-phenyl-3-imidazo[1,2-a]pyridinyl)methyl]morpholine
0
imidazoles00low000000
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1h-imidazol-2-yl)benzamide
0
benzamides;
benzodioxoles;
imidazoles;
pyridines		EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor00low000000
1-(3,4-dihydro-2H-quinolin-1-yl)-2-[[1-(4-ethoxyphenyl)-2-imidazolyl]thio]ethanone
0
imidazoles00low000000
2-[[1-(3-methoxyphenyl)-2-imidazolyl]thio]-N-(5-methyl-3-isoxazolyl)acetamide
0
imidazoles00low000000
N-(4-tert-butylphenyl)-2-[4-(1-imidazolyl)phenoxy]acetamide
0
imidazoles00low000000
2-[[4-(3,4-dimethylphenyl)-1-phenyl-2-imidazolyl]thio]-N-(1,1-dioxo-3-thiolanyl)acetamide
0
imidazoles00low000000
6-(4-methoxyphenyl)-N,3-dimethyl-2-imidazo[2,1-b]thiazolecarboxamide
0
imidazoles00low000000
eprosartan
0
dicarboxylic acid;
imidazoles;
thiophenes		angiotensin receptor antagonist;
antihypertensive agent;
environmental contaminant;
xenobiotic		00low000000
neticonazole
0
aromatic ether;
benzenes;
conazole antifungal drug;
enamine;
imidazole antifungal drug;
imidazoles;
methyl sulfide		antifungal drug;
EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor		00low000000
2-(2-chlorophenyl)-9-(3-methylphenyl)-8-oxo-7H-purine-6-carboxamide
0
imidazoles00low000000
N-[(3-methyl-6-imidazo[2,1-b]thiazolyl)methyl]-1-propanesulfonamide
0
imidazoles00low000000
oxiconazole
0
conazole antifungal drug;
dichlorobenzene;
imidazole antifungal drug;
imidazoles;
oxime O-ether		antiinfective agent00low000000
3-[(1S)-1-phenylethyl]-4-imidazolecarboxylic acid ethyl ester
0
imidazoles00low000000
d 4476
0
imidazoles00low000000
azanidazole
0
C-nitro compound;
imidazoles		00low000000
4-[4-(4-fluorophenyl)-2-(4-methylsulfonylphenyl)-1H-imidazol-5-yl]pyridine
0
imidazoles00low000000
N-[5-(2-imidazo[1,2-a]pyrimidinyl)-2-methoxyphenyl]-2-methylpropanamide
0
imidazoles00low000000
4-[3-(3-methylanilino)-2-imidazo[1,2-a]pyrimidinyl]phenol
0
imidazoles00low000000
2-[4-(dimethylamino)phenyl]-N-(4-methylphenyl)-3-imidazo[1,2-a]pyrimidinamine
0
imidazoles00low000000
N-(1,3-benzodioxol-5-yl)-2-(4-methylphenyl)-3-imidazo[1,2-a]pyrazinamine
0
imidazoles00low000000
sb-505124
0
benzodioxole;
imidazoles;
methylpyridines		TGFbeta receptor antagonist00low000000
cyazofamid
0
imidazole fungicide;
imidazoles;
nitrile;
organochlorine compound;
sulfamides;
sulfonamide fungicide		antifungal agrochemical;
mitochondrial cytochrome-bc1 complex inhibitor		00low000000
npi 2358
0
2,5-diketopiperazines;
benzenes;
imidazoles;
olefinic compound		angiogenesis inhibitor;
antineoplastic agent;
apoptosis inducer;
microtubule-destabilising agent		00low000000
l-779,450
0
imidazoles00low000000
chir 99021
0
aminopyridine;
aminopyrimidine;
cyanopyridine;
diamine;
dichlorobenzene;
imidazoles;
secondary amino compound		EC 2.7.11.26 (tau-protein kinase) inhibitor00low000000
4-(6-iodo-2-imidazo[1,2-a]pyridinyl)-N,N-dimethylaniline
0
imidazoles00low000000
eluxadoline
0
amino acid amide;
benzamides;
imidazoles;
L-phenylalanine derivative;
methoxybenzoic acid		delta-opioid receptor antagonist;
gastrointestinal drug;
kappa-opioid receptor agonist;
mu-opioid receptor agonist		00low000000
cenicriviroc
0
aromatic ether;
benzazocine;
diether;
imidazoles;
secondary carboxamide;
sulfoxide		anti-HIV agent;
anti-inflammatory agent;
antirheumatic drug;
chemokine receptor 2 antagonist;
chemokine receptor 5 antagonist		00low000000
4-(3-cyclohexyl-5-(4-fluoro-phenyl)-3h-imidazol-4-yl)pyrimidin-2-ylamine
0
aminopyrimidine;
imidazoles;
monofluorobenzenes		EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor00low000000
imidazoleacetic acid ribotide
0
imidazoles;
monocarboxylic acid;
N-glycosyl compound;
ribose monophosphate		00low000000
cefpodoxime
0
imidazoles00low000000
sgi 1776
0
imidazoles00low000000
bms-790052
0
biphenyls;
carbamate ester;
carboxamide;
imidazoles;
valine derivative		antiviral drug;
nonstructural protein 5A inhibitor		00low000000
9-(3,5-difluorophenyl)-6-(ethylamino)-2-purinecarbonitrile
0
imidazoles00low000000
chir 98014
0
aminopyrimidine;
C-nitro compound;
diaminopyridine;
dichlorobenzene;
imidazoles;
secondary amino compound		antineoplastic agent;
apoptosis inducer;
EC 2.7.11.26 (tau-protein kinase) inhibitor;
hypoglycemic agent;
tau aggregation inhibitor;
Wnt signalling activator		00low000000
ledipasvir
0
azaspiro compound;
benzimidazole;
bridged compound;
carbamate ester;
carboxamide;
fluorenes;
imidazoles;
L-valine derivative;
N-acylpyrrolidine;
organofluorine compound		antiviral drug;
hepatitis C protease inhibitor		00low000000
gs-5816
0
carbamate ester;
ether;
imidazoles;
L-valine derivative;
N-acylpyrrolidine;
organic heteropentacyclic compound;
ring assembly		antiviral drug;
hepatitis C virus nonstructural protein 5A inhibitor		00low000000
mk-8742
0
carbamate ester;
imidazoles;
L-valine derivative;
N-acylpyrrolidine;
organic heterotetracyclic compound;
ring assembly		antiviral drug;
hepatitis C virus nonstructural protein 5A inhibitor;
hepatoprotective agent		00low000000
sb-590885
0
aromatic ether;
imidazoles;
ketoxime;
pyridines;
tertiary amino compound		00low000000
ConditionIndicatedStudiesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
Inflammation0
1
2010201014.0high000100
Innate Inflammatory Response0
1
2010201014.0high000100